2025 NFL Week 7 Rams vs. Jaguars line, odds: Expert reveals pick for Sunday's London matchup

Teams contending for their respective division leads meet when the Los Angeles Rams face the Jacksonville Jaguars in London, England, on Sunday morning. Los Angeles is coming off a 17-3 win at Baltimore, while Jacksonville dropped a 20-12 decision to Seattle this past week. The Rams (4-2), who are tied for the NFC West lead, are 2-1 on the road this season. The Jaguars (4-2), who are second and one game behind the Indianapolis Colts in the AFC South, are 3-1 as the home team in 2025. Los Angeles wide receiver Puka Nacua (ankle) will not play.

Kickoff from Wembley Stadium is set for 9:30 a.m. ET. The Rams lead the all-time series 5-1, including wins in each of the last three meetings. The Rams are 3-point favorite in the latest Rams vs. Jaguars odds, while the over/under for total points scored is 44.5. The Rams are -167 on the money line.

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Before making any Rams vs. Jaguars picks, you NEED to see which side SportsLine NFL expert Larry Hartstein is on, considering his mastery of picks involving the Rams.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. He is coming off a down 2024 NFL season at SportsLine that puts him at 967-821 all-time on NFL sides and props (plus 13.8 units), including 593-518 ATS. Entering the 2025-26 season, he has been profitable in five of six seasons, going 659-564 ATS (plus $3,556 for $100 players).

In addition, Hartstein has gone 27-11 on his last 38 picks involving the Rams, returning more than $1,300. Anyone who has followed him could be WAY UP!

Now, Hartstein has locked in another confident against-the-spread pick for Rams vs. Jaguars.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

So who wins Rams vs. Jaguars on Sunday, and what x-factor makes one side of the spread hit HARD? ... Join SportsLine right now to see which side of the Rams vs. Jaguars spread to back, all from the expert who is a blistering 27-11 on picks involving the Rams!

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